6469. Lost in his own revery, he forgot that vicissitudes can change the course of man’s life.

✅ The correct answer is option B.
Difficulties : the state or condition of being difficult.

Change : make or become different.

Impediments : a hindrance or obstruction in doing something.

Unfortunate : having or marked by bad fortune; unlucky.

Vicissitudes : a change of circumstances or fortune, typically one that is unwelcome or unpleasant.

Synonym of Vicissitudes is Change