2765. Hypercalcemia associated with malignancy is most often mediated by _____________? September 27, 2025 by Admin A. Parathyroid hormone ( PTH) B. Parathyroid hormone related protein (PTHrP) C. Interleukin – 6 ( IL- 6) D. Calcitonin ✅ The correct answer is option B. Parathyroid hormone related protein (PTHrP).